Synthetic communications

One??Pot and Convenient Conversion of 5??Azidopyrazole??4??carboxaldehyde to Pyrazolo [3, 4??b] pyridines

A Zheng, W Zhang, J Pan

Index: Zheng, Airong; Zhang, Wei; Pan, Jinhui Synthetic Communications, 2006 , vol. 36, # 11 p. 1549 - 1556

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Citation Number: 12

Abstract

Abstract A one??pot and convenient synthesis of multisubstituted pyrazolo [3, 4??b] pyridines in moderate to high yields has been achieved by a two??step reaction: diazo??transfer of 5?? azido??1??phenylpyrazole??4??carboxaldehydes to ketones in ethanolic KOH to give 5??amino?? 1??phenylpyrazole??4??carboxaldehyde and subsequent Friedlaender reaction of 5??amino??1?? phenylpyrazole??4??carboxaldehyde with ketones.