Advanced Healthcare Materials 2018-02-21

Therapeutic Nucleic Acids: Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids (Adv. Healthcare Mater. 4/2018)

Minjie Sun, Kaikai Wang, David Oupický

Index: 10.1002/adhm.201870018

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Abstract

Polymeric materials responsive to endogenous and exogenous stimuli promise to overcome multitude of barriers faced during systemic delivery of therapeutic nucleic acids. In article number 1701070, David Oupický and co-workers survey successful examples of enhanced nucleic acid delivery using polymers that respond to changes in pH, redox state, enzyme levels, hypoxia, reactive oxygen species, light, ultrasound, and hyperthermia.