Tetrahedron

Regioselective conversion of alkynes to 4-substituted and 3, 4-disubstituted isoxazoles using titanium-catalyzed multicomponent coupling reactions

AA Dissanayake, AL Odom

Index: Dissanayake, Amila A.; Odom, Aaron L. Tetrahedron, 2012 , vol. 68, # 3 p. 807 - 812

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Citation Number: 12

Abstract

Conditions have been developed for the regioselective synthesis of 4-substituted isoxazoles from terminal alkynes and 3, 4-disubstituted isoxazoles from internal alkynes. The methodology involves a one-pot titanium-catalyzed multicomponent coupling reaction followed by simple hydroxylamine hydrochloride addition.