2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

…, JG Breitenbucher, BA Katz, C Luong, A Martelli…

Index: Mackman, Richard L.; Hui, Hon C.; Breitenbucher; Katz, Bradley A.; Luong, Christine; Martelli, Arnold; McGee, Danny; Radika, Kesavan; Sendzik, Martin; Spencer, Jeffrey R.; Sprengeler, Paul A.; Tario, James; Verner, Erik; Wang, Jing Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 15 p. 2019 - 2022

Full Text: HTML

Citation Number: 33

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described. ... The development of potent and selective inhibitors of uPA based on the ...