Polysaccharides from Chinese Liupao dark tea and their protective effect against hyperlipidemia
Yan Mao, Baoyao Wei, Jianwen Teng, Ning Xia, Mouming Zhao, Li Huang, Ying Ye
Index: 10.1111/ijfs.13633
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Abstract
Summary Polysaccharides-rich dark tea is believed to be beneficial to health in Southeast Asian. However, the hypolipidemic effect of Chinese Liupao tea polysaccharides (CLTPS) has not been investigated. Here, the potential mechanism by which the oral administration of CLTPS affects lipid metabolism was evaluated using high-fat diet-induced hyperlipidemia rats. In rats supplemented with CLTPS, a suppressive effect on body weight was observed after 4 weeks of intervention. CLTPS significantly improved the levels of lipid profiles, the oxidation of lipids and antioxidant enzyme activity in a dose-dependent manner. The cholesterol-lowering action was paralleled by the stimulation of cholesterol converted to bile acids along with a 1.5-fold increase in faecal excretion. Besides, the prolongation of coagulation factors and the reduction in fibrinogen content showed that CLTPS regulated the coagulation initiated through the intrinsic pathway. With current findings, CLTPS may be valuable as a natural hypolipidemic nutraceutical for human consumption. CLTPS intake showed significant remarkable protection against dyslipidemia induced by high fat diet as well as the anticoagulant activity on regulating the coagulation. CLTPS intervention may make the contribution to the improvements of hyperlipidemia.