Decomposition of N′??Benzoyl??N??nitrosoureas in Aqueous Media

C Faustino, L García??Río, JR Leis…

Index: Faustino, Celia; Garcia-Rio, Luis; Leis, Jose Ramon; Norberto, Fatima European Journal of Organic Chemistry, 2005 , # 1 p. 154 - 161

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Citation Number: 13

Abstract

Abstract The decomposition of N′-benzoyl-N-methyl-N-nitrosourea (BMNU) in aqueous media over the 0− 14 pH range has been studied. In basic and neutral media (6< pH< 14) the reaction proceeds through abstraction of the acidic proton of BMNU (pK a= 7.8) and subsequent decomposition of the conjugate base of the thus formed nitrosourea, via an intermediate benzoyl isocyanate. Support for this mechanism is provided by the presence ...