Photo-induced anticancer activity and singlet oxygen production of prodigiosenes
Huguette Savoie, Carlotta Figliola, Estelle Marchal, Bry W. Crabbe, Geniece L. Hallett-Tapley, Ross W. Boyle, Alison Thompson
Index: 10.1039/C8PP00060C
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Abstract
The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER− and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.