Benzofuran derivatives. Part 3 On the reactivities of the intermediates in benzofuran synthesis

T Horaguchi, S Matsuda, K Tanemura…

Index: Horaguchi, Takaaki; Matsuda, Shinichi; Tanemura, Kiyoshi; Suzuki, Tsuneo Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 965 - 969

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Citation Number: 12

Abstract

Abstract 3-Methyl-5-nitrobenzofuran (2) and 3-methyl-5-nitrobenzofuran-2-carboxylic acid (3) were obtained by heating 2-acetyl-4-nitrophenoxyacetic acid (1) with various bases in acetic anhydride. It appeared that 3-hydroxy-3-methyl-5-nitro-2, 3-dihydrobenzofuran-2- carboxylic acid (4) was the intermediate in the benzofuran synthesis. The properties of 4 were examined under various conditions. Using strong bases such as triethyl-amine in ...