One-pot synthesis of diarylalkylcarbinols and substituted derivatives through carbon monoxide insertion reactions into aryllithiums

AA Vitale, F Doctorovich, NS Nudelman

Index: Vitale, Arturo A.; Doctorovich, F.; Nudelman, N. Sbarbati Journal of Organometallic Chemistry, 1987 , vol. 332, p. 9 - 18

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Citation Number: 20

Abstract

Abstract The carbonylation of a THF solution of aryllithium (aryl= Ph, o-anisyl) in the presence of an alkyl bromide, RBr; at atmospheric pressure and− 78 C, affords diarylalkylcarbinols in good yields. Alkyl chlorides do not react under similar experimental conditions. This feature makes the reaction particularly useful for the synthesis of alcohols functionalized in the alkyl chain through subsequent reactions of the diaryl (chloro) ...