Dopaminergic agonists: comparative actions of amine and sulfonium analogs of dopamine

A Hamada, YA Chang, N Uretsky…

Index: Hamada, Akihiko; Chang, Yu An; Uretsky, Norman; Miller, Duane D. Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 675 - 680

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Citation Number: 17

Abstract

7 agonist activity and that sulfonium analogues of dopamine, eg, 4, possess significant activity in both dopamine binding and behavioral~ tudies.~ An important approach toward understanding the conformational requirements for drugs acting on dopamine receptors has been to examine molecules possessing a dopamine segment in structures of conformationally restricted molecules, such as 6, 7-dihydroxy-2-aminotetralin

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Methanesulfenic acid chloride Structure

5813-48-9

Methanesulfenic...

1,2-dihydro-6,7-dimethoxynaphthalene Structure

35491-96-4

1,2-dihydro-6,7...

~62%

6,7-dimethoxy-2-(methylthio)naphthalene Structure

33212-93-0

6,7-dimethoxy-2...

6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

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6,7-dimethoxy-3...

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4-(3,4-Dimethoxyphenyl)butanoic acid Structure

13575-74-1

4-(3,4-Dimethox...

~%

6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

89017-46-9

6,7-dimethoxy-3...

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1,2-Dimethoxybenzene Structure

91-16-7

1,2-Dimethoxybenzene

~%

6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

89017-46-9

6,7-dimethoxy-3...

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6,7-dimethoxy-1-hydroxytetraline Structure

35491-95-3

6,7-dimethoxy-1...

~%

6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

89017-46-9

6,7-dimethoxy-3...

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Benzenebutanoic acid,3,4-dimethoxy-g-oxo Structure

5333-34-6

Benzenebutanoic...

~%

6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

89017-46-9

6,7-dimethoxy-3...

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6,7-Dimethoxy-3,4-dihydronaphthalen-1(2H)-one Structure

13575-75-2

6,7-Dimethoxy-3...

~%

6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

89017-46-9

6,7-dimethoxy-3...

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6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

89017-46-9

6,7-dimethoxy-3...

~90%

6,7-dimethoxy-2-methylsulfanyl-1,2,3,4-tetrahydronaphthalene Structure

89017-47-0

6,7-dimethoxy-2...

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4-(3,4-Dimethoxyphenyl)butanoic acid Structure

13575-74-1

4-(3,4-Dimethox...

~%

6,7-dimethoxy-2-methylsulfanyl-1,2,3,4-tetrahydronaphthalene Structure

89017-47-0

6,7-dimethoxy-2...

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1,2-Dimethoxybenzene Structure

91-16-7

1,2-Dimethoxybenzene

~%

6,7-dimethoxy-2-methylsulfanyl-1,2,3,4-tetrahydronaphthalene Structure

89017-47-0

6,7-dimethoxy-2...

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1,2-dihydro-6,7-dimethoxynaphthalene Structure

35491-96-4

1,2-dihydro-6,7...

~%

6,7-dimethoxy-2-methylsulfanyl-1,2,3,4-tetrahydronaphthalene Structure

89017-47-0

6,7-dimethoxy-2...

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6,7-dimethoxy-1-hydroxytetraline Structure

35491-95-3

6,7-dimethoxy-1...

~%

6,7-dimethoxy-2-methylsulfanyl-1,2,3,4-tetrahydronaphthalene Structure

89017-47-0

6,7-dimethoxy-2...

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Benzenebutanoic acid,3,4-dimethoxy-g-oxo Structure

5333-34-6

Benzenebutanoic...

~%

6,7-dimethoxy-2-methylsulfanyl-1,2,3,4-tetrahydronaphthalene Structure

89017-47-0

6,7-dimethoxy-2...

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6,7-Dimethoxy-3,4-dihydronaphthalen-1(2H)-one Structure

13575-75-2

6,7-Dimethoxy-3...

~%

6,7-dimethoxy-2-methylsulfanyl-1,2,3,4-tetrahydronaphthalene Structure

89017-47-0

6,7-dimethoxy-2...

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Methanol Structure

67-56-1

Methanol

6,7-dimethoxy-2-(methylthio)naphthalene Structure

33212-93-0

6,7-dimethoxy-2...

~89%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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4-(3,4-Dimethoxyphenyl)butanoic acid Structure

13575-74-1

4-(3,4-Dimethox...

~%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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1,2-Dimethoxybenzene Structure

91-16-7

1,2-Dimethoxybenzene

~%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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1,2-dihydro-6,7-dimethoxynaphthalene Structure

35491-96-4

1,2-dihydro-6,7...

~%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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6,7-dimethoxy-1-hydroxytetraline Structure

35491-95-3

6,7-dimethoxy-1...

~%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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Benzenebutanoic acid,3,4-dimethoxy-g-oxo Structure

5333-34-6

Benzenebutanoic...

~%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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6,7-Dimethoxy-3,4-dihydronaphthalen-1(2H)-one Structure

13575-75-2

6,7-Dimethoxy-3...

~%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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6,7-dimethoxy-3-methylsulfanyl-1,2-dihydronaphthalene Structure

89017-46-9

6,7-dimethoxy-3...

~%

(6,7-dihydroxynaphthalen-2-yl)-dimethylsulfanium,bromide Structure

89017-42-5

(6,7-dihydroxyn...

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N/A Structure

89017-43-6

N/A

~85%

1-(1,3-benzodioxol-5-yl)-2-methylsulfanylpropan-1-one Structure

89017-45-8

1-(1,3-benzodio...

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1-(1,3-benzodioxol-5-yl)-2-methylsulfinylethanone Structure

56221-32-0

1-(1,3-benzodio...

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1-(1,3-benzodioxol-5-yl)-2-methylsulfanylpropan-1-one Structure

89017-45-8

1-(1,3-benzodio...

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