Tetrahedron 2018-03-07

Cembranoids from Eunicea sp. enhance insulin-producing cells proliferation

G. Porras, A.R. Díaz-Marrero, J.M. de la Rosa, L. D'Croz, N. de Pablo, G. Perdomo, I. Cózar-Castellano, J. Darias, M. Cueto

Index: 10.1016/j.tet.2018.03.011

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Abstract

Nine new cembranoids 1–9 containing an α–methylene–γ–butyrolactone together with the known diterpenes 10–15 have been isolated from a crude extract of Eunicea sp. and their structures were established by spectroscopic methods. The proliferative effect of six of these compounds on insulin-producing cells (beta–cells) was evaluated.