Tetrahedron 2018-03-07

Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base

Najwa Sbei, Belen Batanero, Fructuoso Barba, Beya Haouas, Mohamed Lamine Benkhoud, Isidoro Barba

Index: 10.1016/j.tet.2018.03.010

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Abstract

A new series of 3,4-disubstituted quinazolin-2-ones, with potential T-type calcium channel antagonist activity, and new 4-methylene-quinazolin-2-ones, promising catalysts as N-heterocyclic olefins, have been prepared in good yield by a simple reaction between 2-aminobenzophenone, or 2-aminoacetophenone, and cyanomethyl anion electrogenerated by acetonitrile reduction at a graphite electrode, followed by the addition of different organic isocyanates and subsequent heterocyclization.