Tetrahedron 2018-03-13

Asymmetric ring-opening reaction of azabenzonorbornadienes with phenols promoted by palladium/(R,R)-DIOP complex

Zhen Xiu He, Yong Yun Zhou, Baiqiu Han, Xin Xu, Yun Li, Hongyu Qin, Ruifeng Fan, Laishram Ronibala Devi, Baomin Fan

Index: 10.1016/j.tet.2018.03.029

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Abstract

An efficient asymmetric ring opening reaction of azabenzonorbornadienes with various phenols using Palladium/(R,R)-DIOP complex has been demonstrated, the reaction afforded the corresponding products in excellent yields (80–95%) with moderate enantioselectivities (50–64% ees). The syn-configuration of the product was codnfirmed by the single X-ray crystallography.