Tetrahedron 2018-03-14

A mechanistic investigation of an Iridium-catalyzed asymmetric hydrogenation of pyridinium salts

Yuhua Huang, Shaodong Liu, Yizhou Liu, Yonggang Chen, Mark Weisel, R. Thomas Williamson, Ian W. Davies, Xumu Zhang

Index: 10.1016/j.tet.2018.03.031

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Abstract

NMR studies of the catalyst, deuteration experiments, mass spectrometry, and isolation and characterization of intermediates, allow us to propose an outer-sphere mechanism for the Iridium-catalyzed asymmetric hydrogenation of N-alkyl-2-arylpyridinium salts.