Synthesis 2018-03-28

Organocatalytic Electrochemical C–H Lactonization of Aromatic Carboxylic Acids

Li, Longji, Yang, Qi, Jia, Zongbin, Luo, Sanzhong

Index: 10.1055/s-0036-1591558

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Abstract

An electrochemical strategy has been developed for radical arene carbon–oxygen bond formation. This reaction utilizes DDQ as a redox mediator, with inexpensive glassy carbon electrodes to facilitate an intramolecular lactonization of biphenyl-2-carboxylic acid derivatives via aromatic carboxyl radical substitution to give 6H-benzo[c]chromen-6-ones.