Advanced Synthesis and Catalysis 2018-04-16

Palladium‐Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine‐Containing 1,1‐Diarylethylenes

Junqing Liang; Guozhi Huang; Peng Peng; Tianyu Zhang; Jingjing Wu; Fanhong Wu

Index: 10.1002/adsc.201701569

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Abstract

A palladium(0)‐catalyzed three‐component reaction of 2‐iodo‐2,2‐difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1‐benzoyldifluoromethyl‐2,2‐diphenylethylenes in good yields and with excellent stereoselectivity. The 1‐benzoyldifluoromethyl‐2,2‐diphenylethylene products synthesized through a radical reaction process are versatile synthons for the construction of various fluorine‐containing compounds, which have antiproliferative activity on human tumor cells.