Tetrahedron 2018-04-06

Total Synthesis of Sch 725674

Kannan Vaithegi, Kavirayani R. Prasad

Index: 10.1016/j.tet.2018.04.014

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Abstract

A concise total synthesis of the macrolactone natural product Sch 725674 is accomplished starting from commercially available 2-deoxy-d-ribose. Pivotal reactions employed in the synthesis include the addition of 4-pentenylmagnesium bromide to the lactol derived from 2-deoxy-d-ribose, olefin cross metathesis and Yamaguchi macrolactonization.