The scarcity of effective inhibitors of protein tyrosine phosphatase has led to a search for other small molecule inhibitors. Pulchellalactam (1) has been shown to possess remarkable inhibitory action against CD45. However, because of its limited availability from the marine source, there is a need to obtain this molecule in sufficient amounts through synthetic endeavors. ... View all references reported the first total synthesis of (1) in six??steps starting from N??boc??glycine ...
