The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2, 5-dimethoxyphenyl) pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n= 15), shows the most potent promotion of axonal growth in the presence of both permissive and non- permissive naturally occurring substrates such as Sema3A and myelin proteins.
