Influence of 6-or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo [1, 2-a] pyridine against human cytomegalovirus (CMV) and varicella-zoster virus …

…, H Allouchi, C Enguehard-Gueiffier, R Snoeck…

Index: Veron, Jean-Baptiste; Allouchi, Hassan; Enguehard-Gueiffier, Cecile; Snoeck, Robert; Andrei, Graciela; De Clercq, Erik; Gueiffier, Alain Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 21 p. 9536 - 9545

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Citation Number: 49

Abstract

The synthesis of original imidazo [1, 2-a] pyridines bearing a thioether side chain at the 3 position and diversely substituted on the 6 or 8 position, and their antiviral activities are reported. From the synthesized compounds, the imidazo [1, 2-a] pyridines bearing a 5 membered heterocycle (thiophene, furane or pyrrole) in the 6 position or a phenylthio group in the 6 or 8 position (14, 16, 21, 28, 45) were the most potent against human ...