Tetrahedron letters

Fluorous electrophilic scavengers for solution-phase parallel synthesis

W Zhang, CHT Chen, T Nagashima

Index: Zhang, Wei; Chen, Christine Hiu-Tung; Nagashima, Tadamichi Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2065 - 2068

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Citation Number: 62

Abstract

A fluorous isatoic anhydride and isocyanate are synthesized and used as scavengers for amines in solution-phase parallel synthesis of urea, thiourea, and β-hydroxyamine analogs. The resulting fluorous derivatives are readily separated from the reaction mixture by solid- phase extractions (SPE) over FluoroFlash™ cartridges to give products with good purity. The SPE cartridges can be reused.