Direct C–H Bond Arylation of (Benzo) oxazoles with Aryl Chlorides Catalyzed by N-Heterocyclic Carbene–Palladium (II)–1-Methylimidazole Complex

XB Shen, Y Zhang, WX Chen, ZK Xiao, TT Hu…

Index: Shen, Xiao-Bao; Zhang, Yun; Chen, Wen-Xin; Xiao, Zheng-Kang; Hu, Ting-Ting; Shao, Li-Xiong Organic Letters, 2014 , vol. 16, # 7 p. 1984 - 1987

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Citation Number: 31

Abstract

The direct C–H bond arylation of (benzo) oxazoles with aryl chlorides was achieved catalyzed by a well-defined NHC–Pd (II)–Im complex. Under the optimal conditions, various aryl chlorides were successfully applied as the arylating reagents to achieve the 2-aryl (benzo) oxazoles in acceptable to high yields, providing a convenient and alternative method for the direct C–H bond arylation of (benzo) oxazoles and enriching the chemistry ...

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