N-(5-chloro-1, 3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl) ethoxy]-5-(tetrahydro-2 h-pyran-4-yloxy) quinazolin-4-amine, a novel, highly selective, orally available, …

…, C Lambert-van der Brempt, R Morgentin…

Index: Hennequin, Laurent F.; Allen, Jack; Breed, Jason; Curwen, Jon; Fennell, Michael; Green, Tim P.; Lambert-Van Der Brempt, Christine; Morgentin, Remy; Norman, Richard A.; Olivier, Annie; Otterbein, Ludovic; Ple, Patrick A.; Warin, Nicolas; Costello, Gerard Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6465 - 6488

Full Text: HTML

Citation Number: 250

Abstract

Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. We report here a novel subseries of C-5-substituted anilinoquinazolines that display high affinity and specificity for the tyrosine kinase domain of the c-Src and Abl enzymes. These compounds exhibit high selectivity for SFKs over a panel of recombinant protein kinases, excellent pharmacokinetics, and in vivo activity following oral dosing. N-(5 ...

 Related Synthetic Route
7-methoxy-5-(N -methylpiperidin-4-yloxy)-3,4-dihydroquinazolin-4-one Structure

379228-53-2

7-methoxy-5-(N ...

~71%

4-chloro-7-methoxy-5-(1-methylpiperidin-4-yl)oxyquinazoline Structure

379228-48-5

4-chloro-7-meth...

[7-methoxy-5-[(1-methylpiperidin-4-yl)oxy]-4-oxoquinazolin-3(4H)-yl]methyl pivalate Structure

379228-52-1

[7-methoxy-5-[(...

~%

4-chloro-7-methoxy-5-(1-methylpiperidin-4-yl)oxyquinazoline Structure

379228-48-5

4-chloro-7-meth...

4-oxo-5-(tetrahydro-2H-pyran-4-yloxy)-3,4-dihydroxyquinazolin-7-yl acetate Structure

379229-33-1

4-oxo-5-(tetrah...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

4-chloro-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-7-yl acetate Structure

379229-95-5

4-chloro-5-(tet...

~78%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

5-hydroxy-7-methoxy-1H-quinazolin-4-one Structure

379228-50-9

5-hydroxy-7-met...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

5,7-Dimethoxy-4(1H)-quinazolinone Structure

379228-27-0

5,7-Dimethoxy-4...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

tert-butyl [(5-hydroxy-7-methoxy-4-oxoquinazolin-3(4H)-yl)-methyl]carbamate Structure

379228-51-0

tert-butyl [(5-...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

7-methoxy-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4(3H)-one Structure

379229-70-6

7-methoxy-5-(te...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

7-hydroxy-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4(3H)-one Structure

379229-71-7

7-hydroxy-5-(te...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

2-Amino-4,6-dimethoxybenzoic acid Structure

21577-57-1

2-Amino-4,6-dim...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

Methyl 2-amino-4,6-dimethoxybenzoate Structure

379228-26-9

Methyl 2-amino-...

~%

4-chloro-5-(oxan-4-yloxy)-3H-quinazolin-7-one Structure

379229-72-8

4-chloro-5-(oxa...

5-Fluoro-4-quinazolinol Structure

436-72-6

5-Fluoro-4-quin...

~%

4-Chloro-5-methoxy-quinazoline Structure

179246-14-1

4-Chloro-5-meth...

5,7-Dimethoxy-4(1H)-quinazolinone Structure

379228-27-0

5,7-Dimethoxy-4...

~99%

5-hydroxy-7-methoxy-1H-quinazolin-4-one Structure

379228-50-9

5-hydroxy-7-met...

Methyl 2-amino-4,6-dimethoxybenzoate Structure

379228-26-9

Methyl 2-amino-...

~%

5-hydroxy-7-methoxy-1H-quinazolin-4-one Structure

379228-50-9

5-hydroxy-7-met...

2-Amino-4,6-dimethoxybenzoic acid Structure

21577-57-1

2-Amino-4,6-dim...

~%

5-hydroxy-7-methoxy-1H-quinazolin-4-one Structure

379228-50-9

5-hydroxy-7-met...

N/A Structure

196207-16-6

N/A

~%

5,7-bis(phenylmethoxy)-1H-quinazolin-4-one Structure

379228-33-8

5,7-bis(phenylm...

2-amino-4,6-bis(benzyloxy)benzoic acid Structure

379228-31-6

2-amino-4,6-bis...

~%

5,7-bis(phenylmethoxy)-1H-quinazolin-4-one Structure

379228-33-8

5,7-bis(phenylm...

5-Fluoro-4-quinazolinol Structure

436-72-6

5-Fluoro-4-quin...

Sodium Methylate Structure

124-41-4

Sodium Methylate

~68%

5-Methoxy-4(1H)-quinazolinone Structure

135106-52-4

5-Methoxy-4(1H)...

2-Amino-4,6-dimethoxybenzoic acid Structure

21577-57-1

2-Amino-4,6-dim...

~%

4-Chloro-5,7-dimethoxyquinazoline Structure

884340-91-4

4-Chloro-5,7-di...

Methyl 2-amino-4,6-dimethoxybenzoate Structure

379228-26-9

Methyl 2-amino-...

~%

4-Chloro-5,7-dimethoxyquinazoline Structure

884340-91-4

4-Chloro-5,7-di...

diazomethane Structure

186581-53-3

diazomethane

2-Amino-4,6-dimethoxybenzoic acid Structure

21577-57-1

2-Amino-4,6-dim...

~96%

Methyl 2-amino-4,6-dimethoxybenzoate Structure

379228-26-9

Methyl 2-amino-...

4,5-Difluoroanthranilic Acid Structure

126674-77-9

4,5-Difluoroant...

Methanol Structure

67-56-1

Methanol

~86%

Methyl 2-amino-4,6-difluorobenzoate Structure

379228-57-6

Methyl 2-amino-...

4,6-Difluoro-1H-indole-2,3-dione Structure

126674-93-9

4,6-Difluoro-1H...

~%

Methyl 2-amino-4,6-difluorobenzoate Structure

379228-57-6

Methyl 2-amino-...

2-Amino-4,6-dimethoxybenzoic acid Structure

21577-57-1

2-Amino-4,6-dim...

~%

5,7-Dimethoxy-4(1H)-quinazolinone Structure

379228-27-0

5,7-Dimethoxy-4...


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved