Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity

…, QX Min, YL Wang, YD Yue, JC Chen

Index: Wan, Luo-Sheng; Min, Qiu-Xia; Wang, Yong-Long; Yue, Yao-Dong; Chen, Jia-Chun Journal of Natural Products, 2013 , vol. 76, # 7 p. 1248 - 1253

Full Text: HTML

Citation Number: 6

Abstract

Ten new xanthone glycosides, kouitchensides A–J (1–10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC50 values in the range 126 to 451 μM) displayed more potent inhibitory ...