A new synthetic route to protected α-hydrazinoesters in high optical purity using the Mitsunobu protocol

…, MF Pinto, J Bodiguel, B Jamart-Grégoire

Index: Brosse, Nicolas; Pinto, Maria-Fatima; Jamart-Gregoire, Brigitte Journal of Organic Chemistry, 2000 , vol. 65, # 14 p. 4370 - 4374

Full Text: HTML

Citation Number: 53

Abstract

Among the variety of amino acid analogues currently investigated in organic chemistry, there is a growing interest in the synthesis of R-hydrazinoacids (2-hydrazinyl acids) which present interesting biological activities1 and can be used for the preparation of (N-aminoamide) peptides2 or (hydrazide) peptides. 2a, 3 A few reaction pathways have been described for the preparation of optically pure R-hydrazinoacids, 1, 4 although these involve laborious ...