Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives

…, J Chevalier, JC Soyfer, A Crémieux, J Barbe

Index: Kayirere, Marie-Gratia; Mahamoud, Abdallah; Chevalier, Jacqueline; Soyfer, Jean-Claude; Cremieux, Andree; Barbe, Jacques European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 55 - 63

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Citation Number: 41

Abstract

4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquinolines, 4-alkoxy-2, 8- dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-quinoline, 2, 8-dimethyl-4-quinolone and 4-hydroxyquinoline used as starting material. Compounds were characterized from 1H and 13C NMR spectra. These drugs were tested against selected gram−, gram+ and mycobacteria strains. A promising ...