Palladium-Catalyzed Synthesis of Benzimidazoles and Quinazolinones from Common Precursors

JER Sadig, R Foster, F Wakenhut…

Index: Sadig, Jessie E. R.; Foster, Radleigh; Willis, Michael C.; Wakenhut, Florian Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9473 - 9486,14

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Citation Number: 40

Abstract

N-(o-Halophenyl) imidoyl chlorides and the corresponding imidates are easily prepared and can be utilized as complementary precursors for the synthesis of important heterocycles. The synthesis of N-substituted benzimidazoles was possible from the palladium-catalyzed reaction of both classes of substrate with a variety of N-nucleophiles. The use of the imidate precursor for the synthesis of N-substituted quinazolinones by incorporation of a ...