Conformational effects on the activity of drugs. 10. Synthesis, conformation, and pharmacological properties of 1-(2, 5-dimethoxyphenyl)-2-aminoethanols and their …

…, B Macchia, F Macchia, P Tognetti…

Index: Epifani, E.; Lapucci, A.; Macchia, B.; Macchia, F.; Tognetti, P.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 254 - 259

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Citation Number: 15

Abstract

In order to obtain a better understanding of the effects that structural parameters have on the changes of adrenergic activity when 1-aryl-2-aminoethanol derivatives are converted into their corresponding 2-arylmorpholine cyclic analogues, we synthesized l-(2, 5- dimethoxyphenyl)-2-aminoethanol derivatives 5-7 and their morpholine analogues 8-10. The preferred conformation of amino alcohols and their cyclic analogues have been ...