Synthesis, cytotoxicity and effects of some 1, 2, 4-triazole and 1, 3, 4-thiadiazole derivatives on immunocompetent cells

…, D Wesselinova, YA Tsenov, P Denkova

Index: Mavrova, Anelia Ts.; Wesselinova, Diana; Tsenov, Yordan A.; Denkova, Pavletta European Journal of Medicinal Chemistry, 2009 , vol. 44, # 1 p. 63 - 69

Full Text: HTML

Citation Number: 122

Abstract

Novel derivatives of 4, 5-substituted-1, 2, 4-triazole-thiones and 2, 5-substituted-1, 3, 4- thiadiazoles were synthesized and evaluated for their cytotoxicity. The biological study indicated that compounds 4-ethyl-5-(4, 5, 6, 7-tetrahydro-1-benzothien-2-yl)-2, 4-dihydro-3H- 1, 2, 4-triazole-3-thione 13, N-ethyl-5-(4, 5, 6, 7-tetrahydro-1-benzothien-2-yl)-1, 3, 4- thiadiazol-2-amine 16, 4-amino-5-(4, 5, 6, 7-tetrahydro-1-benzothien-2-yl)-2, 4-dihydro-3H ...