Journal of medicinal chemistry

Analogs of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors

JW Daly, WL Padgett, MT Shamim

Index: Daly, J. W.; Padgett, W. L.; Shamim, M. T. Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1305 - 1308

Full Text: HTML

Citation Number: 138

Abstract

Salt (16). 2-Phenylethyl isocyanate (2.94 g, 20 mmol) in 10 mL of dioxane was mixed with potassium metabisulfite (2.22 g, 10 mmol) in 10 mL of water and the mixture stirred overnight. The precipitated solid was collected by suction and washed with acetone. A 5.13- g (96%) sample of pure salt was obtained: IR (KBr) 3300 cm-'(NH), 1660 (C= O); NMR (Me2SO-d6) 6 7.3 (s, 5 H), 3.5 (t, 2 H), 2.8 (t, 3 H). Anal.(C9HloNS04K) C, H, N, S. Enzyme ...