(+)-(2R, 5S)-4-[4-Cyano-3-(trifluoromethyl) phenyl]-2, 5-dimethyl-N-[6-(trifluoromethyl) pyridin-3-yl] piperazine-1-carboxamide (YM580) as an Orally Potent and …

I Kinoyama, N Taniguchi, A Toyoshima…

Index: Journal of Medicinal Chemistry, , vol. 49, # 2 p. 716 - 726

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Citation Number: 26

Abstract

... Journal of Medicinal Chemistry. ... 2. Chemistry. As shown in Scheme 1, two general synthetic procedures were adopted to obtain the target urea derivatives. Our first approach involved the coupling of in situ intermediate ...