Studies on. BETA.-lactam antibiotics. XIV Synthesis and biological activity of the (E)-isomer of FK027.

/宮井健二， 高杉寿， 高谷隆男, T TAKAYA

Index: Kawabata; Miyai; Takasugi; Takaya Chemical and Pharmaceutical Bulletin, 1986 ,  vol. 34,  # 8  p. 3458 - 3464

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Citation Number: 6

Abstract

The (E)-isomer (11) of FK027 was synthesized by two methods. The effect of the configuration of the oxime in the 7-acyl side chain of FK027 (1) on the antimicrobial activity and oral absorbability in rats was investigated. Both FK027 (1) and its (E)-isomer (11)