e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of 4??Substituted??and 1, 4??Disubstituted??4??hydroxypyrrolidin??2??ones
CR Kinsinger, CD Tatko, CM Whelan…
Index: Kinsinger, Christopher R.; Tatko, Chad D.; Whelan, Christopher M.; Wilkinson, Timothy J. Synthetic Communications, 2007 , vol. 37, # 11 p. 1845 - 1852
This report describes the synthesis of 4??substituted?? and 1,4??disubstituted??4??hydroxypyrrolidin ??2??ones by cyclization of intermediate γ??aminoesters prepared from alkylbenzylamines, α??bromoketones, and lithio ethyl acetate. ... This report describes the synthesis of 4??substituted?? and 1,4??disubstituted??4??hydroxypyrrolidin??2??ones by cyclization of intermediate γ??aminoesters prepared from alkylbenzylamines, α??bromoketones, and lithio ethyl acetate.
