Tetrahedron

A facile generation of C–S bonds via one-pot, odourless and efficient thia-Michael addition reactions using alkyl, aryl or allyl halides, thiourea and electron-deficient …

H Firouzabadi, N Iranpoor, M Abbasi

Index: Firouzabadi, Habib; Iranpoor, Nasser; Abbasi, Mohammad Tetrahedron, 2009 , vol. 65, # 27 p. 5293 - 5301

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Citation Number: 44

Abstract

An efficient and odourless synthesis of thia-Michael adducts by the reaction of various organic halides (primary, secondary, tertiary, allylic, and benzylic), structurally diverse electron-deficient alkenes (ketones, esters, and acrylonitrile) and thiourea in the presence of sodium carbonate in wet polyethylene glycol (PEG 200) at 30–35° C has been developed. This protocol is also a highly useful method for large-scale operation.