Tetrahedron

Reductive defluorination of fluoroalkanes

D Guijarro, P Martı́nez, M Yus

Index: Guijarro, David; Martinez, Pedro; Yus, Miguel Tetrahedron, 2003 , vol. 59, # 8 p. 1237 - 1244

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Citation Number: 18

Abstract

The reaction of an excess of lithium powder and a catalytic amount of DTBB with primary, secondary and tertiary fluoroalkanes in the presence of a substoichiometric amount of 1, 2- bis (trimethylsilyl) benzene 1 afforded the corresponding alkanes resulting from a fluorine– hydrogen exchange. The method could be extended to non-geminal difluorides. The effect of the disilylated compound in the naphthalene-catalysed lithiation of fluorobenzene and ...