A flexible, palladium??catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones

…, C Schneider, A Lindenschmidt…

Index: Nazare, Marc; Schneider, Claudia; Lindenschmidt, Andreas; Will, David William Angewandte Chemie - International Edition, 2004 , vol. 43, # 34 p. 4526 - 4528

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Citation Number: 102

Abstract

The optimized reaction conditions, using K3PO4/acetic acid and [Pd (tBu3P) 2], are very broadly applicable and tolerate a wide variety of substitution patterns and functionalities (Scheme 1, Tables 2 and 3). Cyclic ketones with various ring sizes and functionalization react with comparable efficiency (Table 2, entries 1–3), and even acid-labile moieties, such as dioxolane, are stable under the reaction conditions (entry4). The breadth of the 2- ...