e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis and stereostructure–activity relationship of three asymmetric center pyrethroids: 2-methyl-3-phenylcyclopropyl-methyl 3-phenoxybenzyl ether and …
2-Methyl-3-phenylcyclopropylmethyl 3-phenoxybenzyl ether 2 and cyanohydrin ester 3, a couple of pyrethroids with three asymmetric centers, were synthesized. Of each of the four diastereomers of 2 and 3, only the (1R*, 2R*, 3R*)-2a and 3a showed significant insecticidal activities. Dual sets of enantiomers [(1R, 2R, 3R)-(−)-2a and (1S, 2S, 3S)-(+)-2a] and [(1R, 2R, 3R)-(−)-3a and (1S, 2S, 3S)-(+)-3a] were synthesized through the asymmetric ...
