Enzymatic preparation of (1S, 2R)-and (1R, 2S)-stereoisomers of 2-halocycloalkanols

…, AO Kolodiazhna, OI Kolodiazhnyi

Index: Kolodiazhna, Olga O.; Kolodiazhna, Anastasy O.; Kolodiazhnyi, Oleg I. Tetrahedron Asymmetry, 2013 , vol. 24, # 1 p. 37 - 42

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Citation Number: 7

Abstract

The stereoisomers of cis-2-halocycloalkanols were resolved by a kinetically controlled transesterification with vinyl acetate in the presence of lipases in organic media. High enantioselectivities (ee> 98%) and good isolated yields were obtained for all substrates using the appropriate lipase. Burkholderia cepacia lipase was the most efficient enzyme for the resolution of these substrates. The enantiomeric purities of the compounds were ...