Tetrahedron letters

A facile one-pot synthesis of β-keto sulfones from ketones under solvent-free conditions

D Kumar, S Sundaree, VS Rao, RS Varma

Index: Kumar, Dalip; Sundaree, Swapna; Rao; Varma, Rajender S. Tetrahedron Letters, 2006 , vol. 47, # 25 p. 4197 - 4199

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Citation Number: 39

Abstract

An easy solvent-free method is described for the conversion of ketones into β-keto sulfones in high yields that involves the in situ generation of α-tosyloxyketones, followed by nucleophilic substitution with sodium arene sulfinate in the presence of tetra- butylammonium bromide at room temperature. The salient features of this one-pot protocol are short reaction times, cleaner reaction profiles, and simple work-up that precludes the ...

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