Syntheses of indoles via a palladium-catalyzed annulation between iodoanilines and ketones

…, RD Larsen, TR Verhoeven, PJ Reider

Index: Chen; Lieberman; Larsen; Verhoeven; Reider Journal of Organic Chemistry, 1997 , vol. 62, # 9 p. 2676 - 2677

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Citation Number: 145

Abstract

The indole nucleus is a common and important feature of a variety of natural products and medicinal agents. 1 The traditional approach for preparing the indole nucleus is the Fischer indole reaction. 2 As this reaction has shortcomings, the palladium-catalyzed coupling of o- haloanilines is becoming an excellent alternative. 3 A combination of such a palladium- catalyzed reaction with ketones and aldehydes would be a tremendously straightforward ...