Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine. beta.-hydroxylase. 4. …

…, WE DeWolf, JA Finkelstein, JS Frazee…

Index: Kruse, Lawrence I.; Kaiser, Carl; DeWolf, Walter E.; Finkelstein, Joseph A.; Frazee, James S.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 781 - 789

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Citation Number: 48

Abstract

9 aReagents and conditions:(a) BBr,, CHzClz;(b) Raney Ni, EtOH;(c) n-BuLi, EhO;(d) DMF;(e) CO,;(f) NH, OH. HCl;(g) HJRaney Ni;(h) NaBH,, MeOH;(i) NH2CN, AcOH. port the synthesis and in vitro DBH-inhibitory potency of some new multisubstrate inhibitors that resulted from a systematic exploration of ligand replacements. Chemistry. Synthesis of compounds 4-12 (Table I) was accomplished from the corresponding l-benzylimidazole-2- ...