Chemistry letters

Synthesis of 2-pyridylpyridines via Aza-Diels-Alder reactions between 3-pyridyl-1, 2, 4-triazines and some vinyl alkanoates

T Shintou, F Ikeuchi, H Kuwabara, K Umihara, I Itoh

Index: Shintou, Taichi; Ikeuchi, Fumiaki; Kuwabara, Hirokazu; Umihara, Ken; Itoh, Isamu Chemistry Letters, 2005 , vol. 34, # 6 p. 836 - 837

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Citation Number: 10

Abstract

In the course of synthetic studies on 2-pyridylpyridine deriv- atives, which have been well known as fundamental building blocks of some potent drugs,1–3 Sauer et al.4 reported the aza- Diels–Alder reaction of 3-(!-pyridyl)-1,2,4-triazine 1 and 2,5- norbornadiene (2) as an attractive synthetic procedure of substi- tuted 2,!-bipyridines 3 in an excellent yield (Eq 1). Their proce- dure, however, contains two serious problems: i) when !-cyano- pyridine was treated in ...