Journal of Fluorine Chemistry

Catalyst-free one-pot synthesis of 1, 4, 5-trisubstituted pyrazoles in 2, 2, 2-trifluoroethanol

H Alinezhad, M Tajbakhsh, M Zare

Index: Alinezhad, Heshmatollah; Tajbakhsh, Mahmood; Zare, Mahboobeh Journal of Fluorine Chemistry, 2011 , vol. 132, # 11 p. 995 - 1000

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Citation Number: 13

Abstract

A simple, efficient and three component one-pot synthesis of 1, 4, 5-trisubstituted pyrazoles by condensation of β-dicarbonyls, N, N-dimethylformamide dimethyl acetal (DMFDMA) and hydrazine derivatives in 2, 2, 2-trifluoroethanol without using any catalyst and activation, is described.