e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies

…, L Mosti, L Sansebastiano, P Fossa…

Index: Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito Farmaco, 1993 , vol. 48, # 3 p. 335 - 355

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Citation Number: 22

Abstract

The synthesis of ethyl or methyl 4-substituted or unsubstituted 2-(dimethylamino)-5- pyrimidinecarboxylates 10-20, which is mainly carried out by reaction of ethyl or methyl 2- [(dimethylamino) methylene]-3-oxoalkanoates with 1, 1-dimethylguanidine, is described.

Ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate Structure

Ethyl 2-amino-4...

~80%

2-Amino-4-(trifluoromethyl)pyrimidine-5-carboxylic acid Structure

2-Amino-4-(trif...

ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate Structure

ethyl 2-(ethoxy...

~%

2-Amino-4-(trifluoromethyl)pyrimidine-5-carboxylic acid Structure

2-Amino-4-(trif...

acetamidine Structure

ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate Structure

ethyl 2-(ethoxy...

~72%

ethyl 2-methyl-4-(trifluoromethyl)pyrimidine-5-carboxylate Structure

ethyl 2-methyl-...

METHYL THIOPSEUDOUREA SULFATE Structure

METHYL THIOPSEU...

ethyl 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate Structure

ethyl 2-(ethoxy...

~58%

ETHYL 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Structure

ETHYL 2-(METHYL...

4-methyl-2-(methylthio)pyrimidine-5-carboxylic acid Structure

4-methyl-2-(met...

~73%

4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE Structure

4-METHYL-2-(MET...

2-Amino-4-(trifluoromethyl)pyrimidine-5-carboxylic acid Structure

2-Amino-4-(trif...

~76%

2-amino-4-trifluoromethylpyrimidine Structure

2-amino-4-trifl...

Ethyl 2-(methylthio)-4-phenylpyrimidine-5-carboxylate Structure

Ethyl 2-(methyl...

~%

2-(Methylsulfanyl)-4-phenylpyrimidine Structure

2-(Methylsulfan...

METHYL THIOPSEUDOUREA SULFATE Structure

METHYL THIOPSEU...

2-Dimethylaminomethylen-acetessigsaeureethylester Structure

2-Dimethylamino...

~79%

Ethyl 4-Methyl-2-(methylthio)-5-pyrimidinecarboxylate Structure

Ethyl 4-Methyl-...

2-(methylthio)-4-phenylpyrimidine-5-carboxylic acid Structure

2-(methylthio)-...

~70%

2-(Methylsulfanyl)-4-phenylpyrimidine Structure

2-(Methylsulfan...

ETHYL 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Structure

ETHYL 2-(METHYL...

~%

4-trifluoromethyl-2-methylthio-pyrimidine Structure

4-trifluorometh...