Tetrahedron letters

Selective acceleration for deprotection of benzyl ethers with Ti-HMS

A Itoh, T Kodama, S Maeda, Y Masaki

Index: Itoh, Akichika; Kodama, Tomohiro; Maeda, Shiro; Masaki, Yukio Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9461 - 9464

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Citation Number: 28

Abstract

Ti-HMS, a Ti-loaded hexagonal mesoporous silica, was found to accelerate deprotection of benzyl ethers under hydrogenolytic conditions with palladium catalyst. Such acid-sensitive functional groups as silyl ether and acetal moieties in the molecule were little affected by Ti- HMS, which possesses Lewis acid sites due to Ti-atom.