A General Approach to (Trifluoromethoxy) pyridines: First X??ray Structure Determinations and Quantum Chemistry Studies

…, S Pazenok, F Giornal, C Leuenberger…

Index: Manteau, Baptiste; Genix, Pierre; Brelot, Lydia; Vors, Jean-Pierre; Pazenok, Sergiy; Giornal, Florence; Leuenberger, Charlotte; Leroux, Frederic R. European Journal of Organic Chemistry, 2010 , # 31 p. 6043 - 6066

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Citation Number: 10

Abstract

Abstract The previously unknown 2-, 3-, and 4-(trifluoromethoxy) pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of ( ...