Abstract A series of o-, m-and p-benzyl tetrazole derivatives 11a–c has been designed, synthesized and evaluated as potential Angiotensin II AT1 receptor antagonists, based on urocanic acid. Compound 11b with tetrazole moiety at the m-position showed moderate, however, higher activity compared to the o-and p-counterpart analogues. Molecular modelling techniques were performed in order to extract their putative bioactive ...