Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca 2+ release from sarcoplasmic reticulum of mouse …

…, H Aoyama, T Ikemoto, Y Kihara, T Hiramatsu…

Index: Hosoya, Takamitsu; Aoyama, Hiroshi; Ikemoto, Takaaki; Kihara, Yasutaka; Hiramatsu, Toshiyuki; Endo, Makoto; Suzuki, Masaaki Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 5 p. 663 - 673

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Citation Number: 33

Abstract

The general synthesis of dantrolene analogues with various substituents on its phenyl ring has been developed via palladium-catalyzed cross-coupling reactions, the Stille or Suzuki reaction, as the key step. The effects of synthesized analogues have been evaluated by two kinds of Ca2+ release modes from sarcoplasmic reticulum (SR) of mouse skeletal muscle fibers based on:(1) the measurement of twitch contraction caused by the physiological ...