Tetrahedron: Asymmetry

Efficient pathways to (R)-and (S)-5-hydroxymethyl-2-oxazolidinone and some derivatives

K Danielmeier, E Steckhan

Index: Danielmeier, Karsten; Steckhan, Eberhard Tetrahedron: Asymmetry, 1995 , vol. 6, # 5 p. 1181 - 1190

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Citation Number: 47

Abstract

2-Oxazolidinones are a very interesting class of compounds due to their various pharmacological effects. Two new syntheses of enantiomerically pure (R)-and (S)-5- hydroxymethyl-2-oxazolidinone have been developed starting with D-mannitol, L-ascorbic acid and (R)-or (S)-malic acid.(R)-and (S)-5-hydroxymethyl-2-oxazolidinone have been used to synthesize some new homochiral 2-oxazolidinone derivatives.