Tetrahedron Letters

Straightforward synthesis of nitroolefins by microwave-or ultrasound-assisted Henry reaction

JM Rodríguez, MD Pujol

Index: Rodriguez, Jose M.; Dolors Pujol Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2629 - 2632

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Citation Number: 25

Abstract

Abstract β-Nitroalcohol or nitroethylene derivatives can be obtained from aryl aldehydes and nitromethane under Henry condensation conditions. We present a new modification using microwave irradiation or ultrasound as the energy source. Microwave irradiation allowed a novel one-pot synthesis of nitroolefins from aryl aldehydes using ammonium acetate as a catalyst without solvent. Different reaction conditions, such as base, solvent, and reaction ...